Author: Tarakhovsky, Alexander; Prinjha, Rab K.
Title: Drawing on disorder: How viruses use histone mimicry to their advantage Document date: 2018_7_2
ID: ti0avcqy_26
Snippet: Overall, the NS1 tail could be viewed as a highly interactive, internally disorganized motif where amino acid variations contribute to target specificity and hence to the unique features of individual virus subtypes. This feature of NS1, which was recently underscored by a study showing that the NS1 domain interacts with the chromatin remodeling protein CHD1 (Qin et al., 2014) , might be critical in the ability of different influenza subtypes to .....
Document: Overall, the NS1 tail could be viewed as a highly interactive, internally disorganized motif where amino acid variations contribute to target specificity and hence to the unique features of individual virus subtypes. This feature of NS1, which was recently underscored by a study showing that the NS1 domain interacts with the chromatin remodeling protein CHD1 (Qin et al., 2014) , might be critical in the ability of different influenza subtypes to choose their optimal strategy for the host-pathogen interaction, based on the genetic and epigenetic state of the infected host during the emergence of infection. In turn, the counterselection against certain viral subtypes, including some of the NS1 tail-less viruses, could be explained by the inability of NS1 to match host factors, including those localized in the cell nucleus.
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