Author: Spence, Jennifer S.; Krause, Tyler B.; Mittler, Eva; Jangra, Rohit K.; Chandran, Kartik
Title: Direct Visualization of Ebola Virus Fusion Triggering in the Endocytic Pathway Document date: 2016_2_9
ID: tnaizwxo_23
Snippet: Entry by virions bearing precleaved EBOV GP remains sensitive to inhibitors of host cysteine cathepsin activity, suggesting the existence of an additional protease-dependent step in filovirus membrane fusion (19, 35, 60) . Surprisingly, however, our experiments revealed that lipid mixing by cleaved GP was entirely unaffected by inhibition of host cysteine cathepsin activity, even as infectivity was ablated (as reported previously) (Fig. 8) . The .....
Document: Entry by virions bearing precleaved EBOV GP remains sensitive to inhibitors of host cysteine cathepsin activity, suggesting the existence of an additional protease-dependent step in filovirus membrane fusion (19, 35, 60) . Surprisingly, however, our experiments revealed that lipid mixing by cleaved GP was entirely unaffected by inhibition of host cysteine cathepsin activity, even as infectivity was ablated (as reported previously) (Fig. 8) . The latter finding is in agreement with that of Simmons et al., who found no evidence of content release by retroviral particles bearing cleaved GP in E-64d-treated cells; however, they were unable to examine lipid mixing consistently in their assay (53) .
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