Efficacy and safety of the nucleoside analog GS-441524 for treatment of cats with naturally occurring feline infectious peritonitis

Pedersen, Niels C; Perron, Michel; Bannasch, Michael; Montgomery, Elizabeth; Murakami, Eisuke; Liepnieks, Molly; Liu, Hongwei

Cats were discharged to their owners when a significant favorable response to treatment was noted, usually within 3-5 days. Owners were instructed during this time on how to properly give subcutaneous injections of the drug and encouraged to continue daily logs on body temperature, activity, appetite, defecation and urination, and weekly body weight measurements. A CBC and serum chemistry panel were done at monthly intervals by local veterinarians or during visits to the VMTH, and any abnormal signs or behaviors were to be noted and promptly reported. Euthanasia, when required, was usually conducted by the owner's veterinarian or, when possible, at UC Davis. Bodies were sealed in plastic bags, immediately refrigerated, and shipped within 2 days or less in insulated containers with ice-packs to UC Davis by overnight express mail. Necropsies were performed by one of the authors (ML) in the Anatomic Pathology Service of the School of Veterinary Medicine, UC Davis. The owner's request for the final disposition of the body was honored.