Author: Shu, Ting; Gan, Tianyu; Bai, Peng; Wang, Xiaotong; Qian, Qi; Zhou, Hui; Cheng, Qi; Qiu, Yang; Yin, Lei; Zhong, Jin; Zhou, Xi
Title: Ebola virus VP35 has novel NTPase and helicase-like activities Document date: 2019_6_20
ID: u3pxycqh_67
Snippet: In conclusion, this study provides the first demonstration of the NTPase/helicase-like activity associated with an NNSV-encoded protein, EBOV VP35, and finds that GuHCl is an inhibitor of not only the in vitro NTPase and helicase-like activities of EBOV VP35, but also the replication/transcription of EBOV minigenome in human cells. These findings uncover an unexpected novel function of EBOV VP35, extend the view of RNA remodelling proteins, provi.....
Document: In conclusion, this study provides the first demonstration of the NTPase/helicase-like activity associated with an NNSV-encoded protein, EBOV VP35, and finds that GuHCl is an inhibitor of not only the in vitro NTPase and helicase-like activities of EBOV VP35, but also the replication/transcription of EBOV minigenome in human cells. These findings uncover an unexpected novel function of EBOV VP35, extend the view of RNA remodelling proteins, provide the evidence that guanidine-containing compounds may serve as potential candidates for anti-EBOV/filovirus drug development by targeting VP35, and shed light on the understanding of EBOV and filovirus replication and pathogenesis.
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