Effective inactivation of a wide range of viruses by pasteurization

Gröner, Albrecht; Broumis, Connie; Fang, Randel; Nowak, Thomas; Popp, Birgit; Schäfer, Wolfram; Roth, Nathan J.

ng processes are an important part of the broad and complementary safety measures by serving as a proactive measure against emerging viruses not screened for and which may be asymptomatic in donors. The broad effectiveness of pasteurization against emerging viruses and other viruses of concern has been evaluated in a multitude of virus validation studies that confirm that pasteurized plasma-derived products can be considered safe regarding these "emerging" viruses. Pasteurization is effective against the flaviviruses WNV and YFV, 24 coronaviruses (SARS-CoV, TGEV), influenzaviruses (H1N1, H5N1), a bunyavirus (LACV), and togaviruses (SINV, SFV) (Fig. 4) , which is consistent with published data for TBEV, 25 Chikungunya virus, 26 and ZIKV. 24, 27 Notably, BVDV used as a standard model virus for HCV in virus validation TBEV and YFV studies was demonstrated to be more heat stable than most of the emerging viruses (Fig. 4) and therefore confirms the use of BVDV as a worse-case model virus for these arboviruses and provides confidence other arthropod-borne viruses such as, for example, Dengue virus, would also be effectively inactivated.