Author: Lin, Mingqun; Liu, Hongyan; Xiong, Qingming; Niu, Hua; Cheng, Zhihui; Yamamoto, Akitsugu; Rikihisa, Yasuko
Title: Ehrlichia secretes Etf-1 to induce autophagy and capture nutrients for its growth through RAB5 and class III phosphatidylinositol 3-kinase Document date: 2016_8_19
ID: x5y551c8_14
Snippet: To demonstrate that host cytosolic molecules are indeed delivered into E. chaffeensis inclusions via autophagy, the autophagy cargo protein human GAPDH 70 was ectopically expressed in E. chaffeensis-infected cells. E. chaffeensis has surface proteases that are required for its replication. 71, 72 Compared with untreated cells (Fig. 5D ), brief treatment with diisopropylfluorophosphate (DFP), an irreversible serine protease inhibitor, increased th.....
Document: To demonstrate that host cytosolic molecules are indeed delivered into E. chaffeensis inclusions via autophagy, the autophagy cargo protein human GAPDH 70 was ectopically expressed in E. chaffeensis-infected cells. E. chaffeensis has surface proteases that are required for its replication. 71, 72 Compared with untreated cells (Fig. 5D ), brief treatment with diisopropylfluorophosphate (DFP), an irreversible serine protease inhibitor, increased the presence of DsRed-GAPDH inside E. chaffeensis inclusions (Fig. 5E ), supporting autophagic delivery of host cytoplasmic molecules into the inclusion lumen.
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