Selected article for: "apoptosis induction and autophagy inhibition"
Author: Fang, H; Liu, A; Dahmen, U; Dirsch, O
Title: Dual role of chloroquine in liver ischemia reperfusion injury: reduction of liver damage in early phase, but aggravation in late phase
  • Document date: 2013_6_27
    • ID: qmut89kb_4
    Snippet: Given that inhibition of inflammation reduces hepatic I/R injury, and that inhibition of autophagy may worsen hepatic I/R injury, we hypothesized that chloroquine, an anti-inflammatory and autophagy inhibitory drug could have a dual effect in liver I/R injury; chloroquine on the one hand could protect the liver against I/R injury via inhibition of inflammatory response, but on the other hand could aggravate liver I/R injury through inhibition of .....
    Document: Given that inhibition of inflammation reduces hepatic I/R injury, and that inhibition of autophagy may worsen hepatic I/R injury, we hypothesized that chloroquine, an anti-inflammatory and autophagy inhibitory drug could have a dual effect in liver I/R injury; chloroquine on the one hand could protect the liver against I/R injury via inhibition of inflammatory response, but on the other hand could aggravate liver I/R injury through inhibition of autophagy and induction of apoptosis. Therefore, the aim of this study was to investigate the preconditioning effects of chloroquine administration on rat hepatic I/R injury.

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