Selected article for: "hepatic expression and mRNA expression"
Author: Fang, H; Liu, A; Dahmen, U; Dirsch, O
Title: Dual role of chloroquine in liver ischemia reperfusion injury: reduction of liver damage in early phase, but aggravation in late phase
  • Document date: 2013_6_27
    • ID: qmut89kb_7
    Snippet: Chloroquine treatment decreases hepatic inflammatory cytokines gene expression. The expression of hepatic mRNA for TNF-a, IL-6, IL-1b and inducible nitric oxide synthase (iNOS) were measured by quantitative PCR. As shown in Figure 2 , following 60-min warm ischemia, hepatic TNF-a, IL-6, IL-1b and iNOS expression levels were increased at 0.5 and 6 h in both vehicle treatment group and chloroquine treatment group when compared with shamoperated con.....
    Document: Chloroquine treatment decreases hepatic inflammatory cytokines gene expression. The expression of hepatic mRNA for TNF-a, IL-6, IL-1b and inducible nitric oxide synthase (iNOS) were measured by quantitative PCR. As shown in Figure 2 , following 60-min warm ischemia, hepatic TNF-a, IL-6, IL-1b and iNOS expression levels were increased at 0.5 and 6 h in both vehicle treatment group and chloroquine treatment group when compared with shamoperated controls. However, chloroquine-treated rats exhibited minimal increases in hepatic TNF-a, IL-6, IL-1b and iNOS mRNA levels compared with vehicle-injected animals, accounting for about a 5-, 20-, 10-and 5-fold decrease at 6 h of reperfusion, respectively.

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