Author: Lin, Mingqun; Liu, Hongyan; Xiong, Qingming; Niu, Hua; Cheng, Zhihui; Yamamoto, Akitsugu; Rikihisa, Yasuko
Title: Ehrlichia secretes Etf-1 to induce autophagy and capture nutrients for its growth through RAB5 and class III phosphatidylinositol 3-kinase Document date: 2016_8_19
ID: x5y551c8_33
Snippet: Our data revealed lack of involvement of MTOR-ULK1-PRKA and ubiquitination pathways in ehrlichial infection. Instead, our data indicate that E. chaffeensis Etf-1, which is secreted at an early stage of infection, is responsible in inducing autophagy by recruiting PIK3C3 and BECN1, because ectopic expression of Etf-1 is sufficient in increasing cellular PtdIns3P levels; and ectopically expressed Etf-1 induces vesicles that colocalize with ATG5 and.....
Document: Our data revealed lack of involvement of MTOR-ULK1-PRKA and ubiquitination pathways in ehrlichial infection. Instead, our data indicate that E. chaffeensis Etf-1, which is secreted at an early stage of infection, is responsible in inducing autophagy by recruiting PIK3C3 and BECN1, because ectopic expression of Etf-1 is sufficient in increasing cellular PtdIns3P levels; and ectopically expressed Etf-1 induces vesicles that colocalize with ATG5 and LC3.
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