Selected article for: "main factor and tissue damage"
Author: Lin, Huayuan; Huang, Qiqi; Guo, Xiaoquan; Liu, Ping; Liu, Weilian; Zou, Yuelong; Zhu, Shuliang; Deng, Guangfu; Kuang, Jun; Zhang, Caiying; Cao, Huabin; Hu, Guoliang
Title: Elevated level of renal xanthine oxidase mRNA transcription after nephropathogenic infectious bronchitis virus infection in growing layers
  • Document date: 2015_12_17
    • ID: t8547tse_30
    Snippet: In conclusion, our results demonstrated that NIBV infection could elevate XOD gene transcription and its serum activity. The elevation of XOD activity could concomitantly lead to increased UA and ROS contents. On one hand, the increase of serum UA could lead to hyperuricemia, which is the main risk factor for UA crystal deposition. On the other hand, the increase of ROS could not only induce decreased antioxidants, but also cause tissue oxidative.....
    Document: In conclusion, our results demonstrated that NIBV infection could elevate XOD gene transcription and its serum activity. The elevation of XOD activity could concomitantly lead to increased UA and ROS contents. On one hand, the increase of serum UA could lead to hyperuricemia, which is the main risk factor for UA crystal deposition. On the other hand, the increase of ROS could not only induce decreased antioxidants, but also cause tissue oxidative damage.

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