Efficacy and safety of the nucleoside analog GS-441524 for treatment of cats with naturally occurring feline infectious peritonitis

Pedersen, Niels C; Perron, Michel; Bannasch, Michael; Montgomery, Elizabeth; Murakami, Eisuke; Liepnieks, Molly; Liu, Hongwei

Cats with FIP frequently presented with higher than normal total serum protein concentration, high serum globulin, low serum albumin levels and a low A:G ratio (Figures 5-7) . Abnormal serum protein values improved progressively and reached normal levels after 8-10 weeks of treatment (Figures 5-7) . The level of total protein was the least informative, as indicated by the weak R 2 value (0.1883) for the trend line ( Figure 5 ). However, a dramatic and transient rise in total protein levels occurred 3 weeks into treatment ( Figure 5 ). It was associated with an increase in serum globulins (Figure 6a ) and occurred at a time when abdominal effusions were rapidly resolving. Plasma globulin levels rose during the first 3 weeks of treatment, peaked, and then slowly dropped to a maximum reference value of 4.5 g/dl or lower by week 9 (Figure 6a ). Although globulin levels over time appeared to indicate the status of treatment, the low R 2 value (0.3621) made this a less reliable indicator of treatment progress.