Author: Lee, Seung Heon; Yang, Dong-Kun; Kim, Ha-Hyun; Cho, In-Soo
Title: Efficacy of inactivated variant porcine epidemic diarrhea virus vaccines in growing pigs Document date: 2018_1_29
ID: w643jf90_2
Snippet: PEDV, a member of the genus Alphacoronavirus in the family Coronaviridae, is a large, enveloped virus that contains a 28 kb single-stranded positive-sense RNA genome encoding three non-structural proteins (replicases ORF1a and 1b, and ORF3) and four structural proteins (the spike [S], envelope, membrane and nucleocapsid [N] proteins) [8, 9] . Among the structural proteins, the S protein is a type I glycoprotein present on the surface of virions t.....
Document: PEDV, a member of the genus Alphacoronavirus in the family Coronaviridae, is a large, enveloped virus that contains a 28 kb single-stranded positive-sense RNA genome encoding three non-structural proteins (replicases ORF1a and 1b, and ORF3) and four structural proteins (the spike [S], envelope, membrane and nucleocapsid [N] proteins) [8, 9] . Among the structural proteins, the S protein is a type I glycoprotein present on the surface of virions that plays an important role in virus attachment to cell receptors, and it is a target for induction of neutralizing antibodies, as it harbors virus-neutralizing epitopes [10] [11] [12] . In addition, the S protein is associated with adaptation of viruses to growth in cell culture and attenuation of PEDV virulence in the natural host [13] . Therefore, the S protein of PEDV has been the subject of sequence diversity investigations aiming to understand the genetic and phylogenetic relationships of PEDV isolates and the epidemic status of PEDV in the field.
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