Elevated level of renal xanthine oxidase mRNA transcription after nephropathogenic infectious bronchitis virus infection in growing layers

Lin, Huayuan; Huang, Qiqi; Guo, Xiaoquan; Liu, Ping; Liu, Weilian; Zou, Yuelong; Zhu, Shuliang; Deng, Guangfu; Kuang, Jun; Zhang, Caiying; Cao, Huabin; Hu, Guoliang

SOD and GSH-PX are free radical scavengers that play a key role in maintenance of the balance between antioxidants and oxidation. SOD is a major defense enzyme for free radical metabolism that clears superoxide anion (O 2 − ), thus preventing cell damage caused by toxic oxygen radicals. GSH-PX eliminates intracellular H2O2 and lipid radicals. The activities of both SOD and GSH-PX reflect the capability of elimination of free radicals in the body. In our study, the activities of serum GSH-PX and SOD decreased significantly in the infected group relative to the control group at 8 and 15 dpi (p ＜ 0.01), while no significant difference but a steadily decreasing trend was observed at 22 dpi. The SOD and GSH-PX levels indicated that chicken's infected with NIBV would induce an increase in ROS, leading to decreased antioxidants in the body. Nath et al. [18] reported that the kidney was vulnerable to attack by ROS. Therefore, the aberrant generation of ROS might be an another pathogenesis of kidney damage in chickens caused by NIBV infection.