Efficacy and safety of the nucleoside analog GS-441524 for treatment of cats with naturally occurring feline infectious peritonitis

Pedersen, Niels C; Perron, Michel; Bannasch, Michael; Montgomery, Elizabeth; Murakami, Eisuke; Liepnieks, Molly; Liu, Hongwei

Focal injection site reactions Injection site reactions were of two types, and whether they were caused by the drug, diluent or both was not determined. Immediate pain reactions were manifested by vocalization, occasional growling and postural changes lasting for 30-60 s. These initial reactions lessened in severity over time as owners became more adept at administering the injection and cats became more adjusted to the routine. Sixteen of 26 treated cats manifested injection site reactions (Table 3) . Reactions were most common during the first 4 weeks and progressed to open sores only in 7/16 cats. Ulcerations healed within 2 weeks by clipping surrounding hair and gently cleaning the wound with a cotton ball soaked in one-part household hydrogen peroxide and two-parts water twice a day. Only three cats had noticeable scars at injection sites. 3 and 4) . Tests for liver and kidney function and levels of amylase/lipase remained normal during and after treatment (supplementary figures S1-S3). The only exception was cat CT53, which had a progressive rise in blood urea nitrogen (BUN) to 35 mg/dl (reference interval [RI] 16-37 µg/dl) and sudden rise in SDMA (20 µg/ dl) (RI 0-14 µg/dl) at 8 weeks into a third round of treatment with the higher 4 mg/kg dosage regimen. Although these signs were still mild in nature, a decision was made to stop treatment out of caution. These abnormalities were not evident on testing 1 month later and the cat is currently in disease remission.