Author: Lin, Mingqun; Liu, Hongyan; Xiong, Qingming; Niu, Hua; Cheng, Zhihui; Yamamoto, Akitsugu; Rikihisa, Yasuko
Title: Ehrlichia secretes Etf-1 to induce autophagy and capture nutrients for its growth through RAB5 and class III phosphatidylinositol 3-kinase Document date: 2016_8_19
ID: x5y551c8_36
Snippet: Although autolysosomal degradation does not ensue in ehrlichial inclusions (to protect the bacteria), serine protease may be involved in autophagic cargo degradation, because treatment with DFP, an irreversible serine protease inhibitor, increased the presence of DsRed-GAPDH inside E. chaffeensis inclusions. E. chaffeensis has surface proteases that are required for its replication. 71, 72 Host cytosolic NPEPPS, which is incorporated into Etf-1 a.....
Document: Although autolysosomal degradation does not ensue in ehrlichial inclusions (to protect the bacteria), serine protease may be involved in autophagic cargo degradation, because treatment with DFP, an irreversible serine protease inhibitor, increased the presence of DsRed-GAPDH inside E. chaffeensis inclusions. E. chaffeensis has surface proteases that are required for its replication. 71, 72 Host cytosolic NPEPPS, which is incorporated into Etf-1 autophagosomes and targeted to E. chaffeensis inclusions, is also expected to aid degradation of autophagic cargo. Ectopic expression of Etf-1 facilitates the class III PtdIns3Kdependent degradation of Q103-GFP that is degraded by NPEPPS via autophagy, 91 supporting the involvement of NPEPPS in Etf-1 autophagosome cargo degradation.
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