Author: Gröner, Albrecht; Broumis, Connie; Fang, Randel; Nowak, Thomas; Popp, Birgit; Schäfer, Wolfram; Roth, Nathan J.
Title: Effective inactivation of a wide range of viruses by pasteurization Document date: 2017_11_16
ID: w19hl2vs_22
Snippet: The nonenveloped virus HAV was inactivated by heat treatment reliably and effectively. In about half of all product intermediates evaluated, no residual infectivity was detected at the end of pasteurization with RFs of at least 5.4 log; RFs in other product intermediates ranged from 3.8 to 4.4 log with only low levels of residual infectivity remaining (Tables 3 and 4 ). The non-enveloped virus CPV, a heat-resistant animal parvovirus, was inactiva.....
Document: The nonenveloped virus HAV was inactivated by heat treatment reliably and effectively. In about half of all product intermediates evaluated, no residual infectivity was detected at the end of pasteurization with RFs of at least 5.4 log; RFs in other product intermediates ranged from 3.8 to 4.4 log with only low levels of residual infectivity remaining (Tables 3 and 4 ). The non-enveloped virus CPV, a heat-resistant animal parvovirus, was inactivated in the order of 1 log after 10 hours at 608C whereas the human pathogenic parvovirus B19V was effectively inactivated (approx. 4 log) in product intermediates except antithrombin (ATIII) and API (Table 3) .
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