Author: Gröner, Albrecht; Broumis, Connie; Fang, Randel; Nowak, Thomas; Popp, Birgit; Schäfer, Wolfram; Roth, Nathan J.
Title: Effective inactivation of a wide range of viruses by pasteurization Document date: 2017_11_16
ID: w19hl2vs_29
Snippet: In conclusion, pasteurization is a proven method in inactivating a wide range of enveloped and nonenveloped viruses of different physicochemical properties. Together with appropriate selection of donors, donations and plasma pools, and further manufacturing steps reducing viruses potentially present in the starting material, pasteurized plasma-derived products have a high safety margin with respect to virus transmission as demonstrated by virus v.....
Document: In conclusion, pasteurization is a proven method in inactivating a wide range of enveloped and nonenveloped viruses of different physicochemical properties. Together with appropriate selection of donors, donations and plasma pools, and further manufacturing steps reducing viruses potentially present in the starting material, pasteurized plasma-derived products have a high safety margin with respect to virus transmission as demonstrated by virus validation studies and confirmed by ongoing hemovigilance. 34
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