Author: Chen, Ai-Lan; Ou, Cai-Wen; He, Zhao-Chu; Liu, Qi-Cai; Dong, Qi; Chen, Min-Sheng
Title: Effect of hepatocyte growth factor and angiotensin II on rat cardiomyocyte hypertrophy Document date: 2012_10_15
ID: y9isrt3v_33
Snippet: This study was the first to directly assess whether there was a combined effect of HGF and Ang II on cardiomyocyte hypertrophy. Based on the increase in [ 3 H]-Leu incorporation, the increased ANF and β-MHC mRNA expression and the increase in cell size in primary cardiomyocytes, we concluded that HGF and Ang II have a combined effect on neonatal cardiomyocyte hypertrophy. In addition, we also demonstrated for the first time that HGF alone can po.....
Document: This study was the first to directly assess whether there was a combined effect of HGF and Ang II on cardiomyocyte hypertrophy. Based on the increase in [ 3 H]-Leu incorporation, the increased ANF and β-MHC mRNA expression and the increase in cell size in primary cardiomyocytes, we concluded that HGF and Ang II have a combined effect on neonatal cardiomyocyte hypertrophy. In addition, we also demonstrated for the first time that HGF alone can potently induce cultured neonatal cardiomyocyte hypertrophy.
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