Author: Jin, Xi; Lian, Jiang-Shan; Hu, Jian-Hua; Gao, Jianguo; Zheng, Lin; Zhang, Yi-Min; Hao, Shao-Rui; Jia, Hong-Yu; Cai, Huan; Zhang, Xiao-Li; Yu, Guo-Dong; Xu, Kai-Jin; Wang, Xiao-Yan; Gu, Jue-Qing; Zhang, Shan-Yan; Ye, Chan-Yuan; Jin, Ci-Liang; Lu, Ying-Feng; Yu, Xia; Yu, Xiao-Peng; Huang, Jian-Rong; Xu, Kang-Li; Ni, Qin; Yu, Cheng-Bo; Zhu, Biao; Li, Yong-Tao; Liu, Jun; Zhao, Hong; Zhang, Xuan; Yu, Liang; Guo, Yong-Zheng; Su, Jun-Wei; Tao, Jing-Jing; Lang, Guan-Jing; Wu, Xiao-Xin; Wu, Wen-Rui; Qv, Ting-Ting; Xiang, Dai-Rong; Yi, Ping; Shi, Ding; Chen, Yanfei; Ren, Yue; Qiu, Yun-Qing; Li, Lan-Juan; Sheng, Jifang; Yang, Yida
Title: Epidemiological, clinical and virological characteristics of 74 cases of coronavirus-infected disease 2019 (COVID-19) with gastrointestinal symptoms Document date: 2020_3_24
ID: zph6r4il_5
Snippet: discharges, according to official reports from the National Health Commission. The epidemiological and clinical characteristics of COVID- 19 in Wuhan have been reported elsewhere, 4 5 with estimated early transmission dynamics presented as the varied basic reproductive numbers (R 0 ) of 2.2 6 and 2.68, 7 indicating a high virus transmission capacity. SARS-CoV-2 was the seventh coronavirus identified with human infection capacity by the Chinese au.....
Document: discharges, according to official reports from the National Health Commission. The epidemiological and clinical characteristics of COVID- 19 in Wuhan have been reported elsewhere, 4 5 with estimated early transmission dynamics presented as the varied basic reproductive numbers (R 0 ) of 2.2 6 and 2.68, 7 indicating a high virus transmission capacity. SARS-CoV-2 was the seventh coronavirus identified with human infection capacity by the Chinese authorities. Its genomic features were revealed in a Wuhan patient, showing 89% and 82% nuclear acid sequence similarity with Bat SARS-CoVZXC21 and human SARS-CoV, 8 respectively. Further functional studies indicated that the spike (S) protein of 2019-nCoV had a high affinity to ACE2, which is responsible for the virus invasion. 9 It is well-known that viral mutations occur during transmission and spreading. Therefore, we would like to know the mutation and transmission ability, virulence change and associated clinical features of SARS-CoV-2 during its spread.
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