Selected article for: "contact tracing and effective contact"
Author: Hellewell, Joel; Abbott, Sam; Gimma, Amy; Bosse, Nikos I; Jarvis, Christopher I; Russell, Timothy W; Munday, James D; Kucharski, Adam J; Edmunds, W John; Funk, Sebastian; Eggo, Rosalind M
Title: Feasibility of controlling COVID-19 outbreaks by isolation of cases and contacts
  • Document date: 2020_2_28
    • ID: ueb7mjnv_2
    Snippet: Isolation of cases and contact tracing becomes less effective if infectiousness begins before the onset of symptoms. 5, 6 For example, the severe acute respiratory syndrome (SARS) outbreak that began in southern China in 2003, was eventually able to be controlled through tracing contacts of suspected cases and isolating confirmed cases because the majority of transmission occurred after symptom onset. 7 These interventions also play a major role .....
    Document: Isolation of cases and contact tracing becomes less effective if infectiousness begins before the onset of symptoms. 5, 6 For example, the severe acute respiratory syndrome (SARS) outbreak that began in southern China in 2003, was eventually able to be controlled through tracing contacts of suspected cases and isolating confirmed cases because the majority of transmission occurred after symptom onset. 7 These interventions also play a major role in response to outbreaks where onset of symptoms and infectiousness are concurrent-eg, Ebola virus disease, 8, 9 Middle East respiratory syndrome (MERS), 10, 11 and many other infections. 12, 13 The effectiveness of isolation and contact-tracing methods hinges on two key epidemiological parameters: the number of secondary infections generated by each new infection and the proportion of transmission that occurs before symptom onset. 5 In addition, successful contact tracing and reducing the delay between symptom onset and isolation are crucial, because, during this time, cases remain in the community where they can infect others until isolation. 6, 14 Transmission before symptom onset could only be prevented by tracing contacts of confirmed cases and testing (and quarantining) those contacts. Cases that do not seek care, potentially because of subclinical infection, are a further challenge to control.

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