Author: Pedersen, Niels C; Kim, Yunjeong; Liu, Hongwei; Galasiti Kankanamalage, Anushka C; Eckstrand, Chrissy; Groutas, William C; Bannasch, Michael; Meadows, Juliana M; Chang, Kyeong-Ok
Title: Efficacy of a 3C-like protease inhibitor in treating various forms of acquired feline infectious peritonitis Document date: 2017_9_13
ID: y13gz4wz_11
Snippet: Cats with clinical signs indicative of neurologic involvement were excluded from the trial based on earlier unpublished experimental studies with GC376. One cat that was a long-term survivor of an earlier pharmacokinetic and efficacy trial of GC376 had a recurrence of FIP manifested by neurologic signs 6 months after what appeared to be successful treatment of acute infection. 6 This cat failed to respond to a repeat course of GC376, which prompt.....
Document: Cats with clinical signs indicative of neurologic involvement were excluded from the trial based on earlier unpublished experimental studies with GC376. One cat that was a long-term survivor of an earlier pharmacokinetic and efficacy trial of GC376 had a recurrence of FIP manifested by neurologic signs 6 months after what appeared to be successful treatment of acute infection. 6 This cat failed to respond to a repeat course of GC376, which prompted a study of the ability of the drug to penetrate into the brain. GC376 levels in the brains of laboratory cats were only 3% of plasma drug concentrations.
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