Selected article for: "clinical trial and long term"
Author: Pedersen, Niels C; Kim, Yunjeong; Liu, Hongwei; Galasiti Kankanamalage, Anushka C; Eckstrand, Chrissy; Groutas, William C; Bannasch, Michael; Meadows, Juliana M; Chang, Kyeong-Ok
Title: Efficacy of a 3C-like protease inhibitor in treating various forms of acquired feline infectious peritonitis
  • Document date: 2017_9_13
    • ID: y13gz4wz_11
    Snippet: Cats with clinical signs indicative of neurologic involvement were excluded from the trial based on earlier unpublished experimental studies with GC376. One cat that was a long-term survivor of an earlier pharmacokinetic and efficacy trial of GC376 had a recurrence of FIP manifested by neurologic signs 6 months after what appeared to be successful treatment of acute infection. 6 This cat failed to respond to a repeat course of GC376, which prompt.....
    Document: Cats with clinical signs indicative of neurologic involvement were excluded from the trial based on earlier unpublished experimental studies with GC376. One cat that was a long-term survivor of an earlier pharmacokinetic and efficacy trial of GC376 had a recurrence of FIP manifested by neurologic signs 6 months after what appeared to be successful treatment of acute infection. 6 This cat failed to respond to a repeat course of GC376, which prompted a study of the ability of the drug to penetrate into the brain. GC376 levels in the brains of laboratory cats were only 3% of plasma drug concentrations.

    Search related documents:
    Co phrase search for related documents
    • acute infection and drug concentration: 1, 2, 3, 4
    • acute infection and experimental study: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13
    • acute infection and long term: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
    • acute infection and neurologic involvement: 1, 2
    • brain penetrate and long term: 1, 2, 3
    • clinical sign and experimental study: 1, 2
    • clinical sign and long term: 1, 2, 3, 4, 5
    • drug ability and long term: 1, 2
    • drug concentration and experimental study: 1
    • drug concentration and long term: 1, 2, 3, 4, 5
    • drug concentration and plasma drug concentration: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17
    • experimental study and long term: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
    • long term and neurologic involvement: 1, 2, 3, 4, 5, 6