Author: Pedersen, Niels C; Kim, Yunjeong; Liu, Hongwei; Galasiti Kankanamalage, Anushka C; Eckstrand, Chrissy; Groutas, William C; Bannasch, Michael; Meadows, Juliana M; Chang, Kyeong-Ok
Title: Efficacy of a 3C-like protease inhibitor in treating various forms of acquired feline infectious peritonitis Document date: 2017_9_13
ID: y13gz4wz_7
Snippet: The present study was designed to evaluate the 3CLpro inhibitor GC376 in a group of cats with naturally occurring FIP. The study did not incorporate a placebo group, because, as noted by Miller and Brody, 7 'the leading ethical position on placebo-controlled clinical trials is that whenever proven effective treatment exists for a given condition, it is unethical to test a new treatment for that condition against placebo'. GC376 was proven to be h.....
Document: The present study was designed to evaluate the 3CLpro inhibitor GC376 in a group of cats with naturally occurring FIP. The study did not incorporate a placebo group, because, as noted by Miller and Brody, 7 'the leading ethical position on placebo-controlled clinical trials is that whenever proven effective treatment exists for a given condition, it is unethical to test a new treatment for that condition against placebo'. GC376 was proven to be highly effective in curing cats of experimentally induced FIP prior to the study and an effective treatment was presumably available. A natural history of disease group substituted for placebo controls. 8 None of the 20 treated cats demonstrated lasting favorable responses to treatments they received prior to GC376 therapy.
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