Author: Lee, Seung Heon; Yang, Dong-Kun; Kim, Ha-Hyun; Cho, In-Soo
Title: Efficacy of inactivated variant porcine epidemic diarrhea virus vaccines in growing pigs Document date: 2018_1_29
ID: w643jf90_34
Snippet: Various types of adjuvants are used in inactivated viral vaccines to induce a protective immune response. Therefore, determination of the optimum adjuvant for a particular vaccine is important. In this study, we compared the ability of experimental vaccines formulated with four adjuvants to induce protective immunity against PEDV. Although none of the vaccinated pigs were completely protected against subsequent viral challenge, they developed a s.....
Document: Various types of adjuvants are used in inactivated viral vaccines to induce a protective immune response. Therefore, determination of the optimum adjuvant for a particular vaccine is important. In this study, we compared the ability of experimental vaccines formulated with four adjuvants to induce protective immunity against PEDV. Although none of the vaccinated pigs were completely protected against subsequent viral challenge, they developed a significantly stronger immune response than that of NVC pigs. The strongest antibody responses were detected in pigs that received the vaccines containing oil-based W/O/W emulsion adjuvants, and the ISA206-based vaccine protected against both disease progression and viral shedding. Similarly, a foot and mouth disease vaccine formulated with ISA201 and ISA206 elicited the strongest antibody response and induced protection against the disease [27] [28] [29] . Such formulations also elicit protective immunity against viral and bacterial pathogens in various mammalian species [30, 31] .
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