Author: Lin, Mingqun; Liu, Hongyan; Xiong, Qingming; Niu, Hua; Cheng, Zhihui; Yamamoto, Akitsugu; Rikihisa, Yasuko
Title: Ehrlichia secretes Etf-1 to induce autophagy and capture nutrients for its growth through RAB5 and class III phosphatidylinositol 3-kinase Document date: 2016_8_19
ID: x5y551c8_3
Snippet: A tick-borne obligatory intracellular bacterium, Anaplasma phagocytophilum, in the family Anaplasmataceae, replicates in neutrophils in LC3-decorated early autophagosomes that are segregated from the endosomal and lysosomal pathway, thereby gaining access to host cytosolic nutrients while escaping autolysosomal degradation. [35] [36] [37] However, unlike A. phagocytophilum, E. chaffeensis replicates in the early endosome-like compartment; 9 wheth.....
Document: A tick-borne obligatory intracellular bacterium, Anaplasma phagocytophilum, in the family Anaplasmataceae, replicates in neutrophils in LC3-decorated early autophagosomes that are segregated from the endosomal and lysosomal pathway, thereby gaining access to host cytosolic nutrients while escaping autolysosomal degradation. [35] [36] [37] However, unlike A. phagocytophilum, E. chaffeensis replicates in the early endosome-like compartment; 9 whether or how autophagy is involved in the ehrlichial infection process is unknown.
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