Author: Pedersen, Niels C; Kim, Yunjeong; Liu, Hongwei; Galasiti Kankanamalage, Anushka C; Eckstrand, Chrissy; Groutas, William C; Bannasch, Michael; Meadows, Juliana M; Chang, Kyeong-Ok
Title: Efficacy of a 3C-like protease inhibitor in treating various forms of acquired feline infectious peritonitis Document date: 2017_9_13
ID: y13gz4wz_29
Snippet: The emergence of a drug-resistant virus was considered in cat CT03, which relapsed with abdominal lesions after an initial favorable response to granulomatous colitis and dry-to-wet abdominal FIP. Granulomatous lesions were still present in the abdomen at the time of necropsy and no gross or microscopic lesions were found in the brain (Table 1) . Therefore, disease recurrence was not related to neurologic disease and persistent FIPV antigen was i.....
Document: The emergence of a drug-resistant virus was considered in cat CT03, which relapsed with abdominal lesions after an initial favorable response to granulomatous colitis and dry-to-wet abdominal FIP. Granulomatous lesions were still present in the abdomen at the time of necropsy and no gross or microscopic lesions were found in the brain (Table 1) . Therefore, disease recurrence was not related to neurologic disease and persistent FIPV antigen was identified in macrophages in granulomatous lesions. A sequence comparison was performed between the 3CLpro of the pretreatment effusions and omentum collected at necropsy 95 days later. However, no aminoacid substitution was found in 3CLpro, indicating that the emergence of a drug-resistant virus was not the cause of the cat's recurrent disease.
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