Author: Pedersen, Niels C; Kim, Yunjeong; Liu, Hongwei; Galasiti Kankanamalage, Anushka C; Eckstrand, Chrissy; Groutas, William C; Bannasch, Michael; Meadows, Juliana M; Chang, Kyeong-Ok
Title: Efficacy of a 3C-like protease inhibitor in treating various forms of acquired feline infectious peritonitis Document date: 2017_9_13
ID: y13gz4wz_30
Snippet: The 3CLpro sequences of pretreatment viral RNA obtained 25 days (CT16), 139 days (CT02), 149 days (CT12) and 231 days (CT10) later at the time of necropsy were also compared. No differences were observed in 3CLpro over this time. Sequences also remained unchanged in CT02, CT16 and CT12 from the times of presentation to necropsy. The viral 3CLpro from lung and spleen of cat CT10, which relapsed twice over 8 months and retreated, had an Asp-to-Ser .....
Document: The 3CLpro sequences of pretreatment viral RNA obtained 25 days (CT16), 139 days (CT02), 149 days (CT12) and 231 days (CT10) later at the time of necropsy were also compared. No differences were observed in 3CLpro over this time. Sequences also remained unchanged in CT02, CT16 and CT12 from the times of presentation to necropsy. The viral 3CLpro from lung and spleen of cat CT10, which relapsed twice over 8 months and retreated, had an Asp-to-Ser substitution at position 25 and a Lys-to-Asp substitution at position 260 compared with virus from pre-treatment abdominal fluid. The exact effects of these mutations on protease function are currently being investigated. It is reported that genetic evolution of viral protein quasi-species arises over time in patients chronically infected with an RNA virus (HCV) and may lead to sporadic amino acid changes. 11
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