Elevated level of renal xanthine oxidase mRNA transcription after nephropathogenic infectious bronchitis virus infection in growing layers

Lin, Huayuan; Huang, Qiqi; Guo, Xiaoquan; Liu, Ping; Liu, Weilian; Zou, Yuelong; Zhu, Shuliang; Deng, Guangfu; Kuang, Jun; Zhang, Caiying; Cao, Huabin; Hu, Guoliang

Gout is a metabolic disorder, and hyperuricemia has been shown to be an independent risk factor for gout [10] . In poultry, avian gout is usually divided into visceral gout and articular gout. Former researchers have defined visceral gout as a disease induced by the accumulation of uric acid crystals in different internal organs that stimulate phagocytosis and initiate the inflammatory cascade [30] . Edwards [9] reported that elevated serum urate levels were closely associated with deposited urate crystals in intrarenal tissues. Uric acid, which is the ultimate decomposition product of endogenous or dietary purines in chickens, is generated by xanthine oxidase (XOD). Previous studies reported that increases in XOD activity were correlated with elevated serum urate levels [13] .