Author: ZHANG, NAICHUN; DENG, JIANNING; WU, FENGYAO; LU, XIANGCHAN; HUANG, LEI; ZHAO, MIN
Title: Expression of arginase I and inducible nitric oxide synthase in the peripheral blood and lymph nodes of HIV-positive patients Document date: 2015_11_23
ID: zvnqiy9p_24
Snippet: In myeloid cells, Arg I downregulates CD3ζ-chain expression, and inhibits the expression of cell cycle regulatory protein D3 and cell cycle regulatory protein-dependent kinase 4, leading to the inhibition of T cell activation and subsequent suppression of the immune function of T cells (37, 38) . This mechanism is important in the immunosuppression of certain inflammation-associated conditions......
Document: In myeloid cells, Arg I downregulates CD3ζ-chain expression, and inhibits the expression of cell cycle regulatory protein D3 and cell cycle regulatory protein-dependent kinase 4, leading to the inhibition of T cell activation and subsequent suppression of the immune function of T cells (37, 38) . This mechanism is important in the immunosuppression of certain inflammation-associated conditions.
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