Selected article for: "ad brain and antimicrobial peptide"
Author: Carter, Chris J.
Title: Genetic, Transcriptome, Proteomic, and Epidemiological Evidence for Blood-Brain Barrier Disruption and Polymicrobial Brain Invasion as Determinant Factors in Alzheimer’s Disease
  • Document date: 2017_9_28
    • ID: tmpidjrp_102
    Snippet: Multiple and diverse pathogens (bacteria, viruses, fungi, and spirochetes) have been detected in the AD brain and many cause neurodegeneration, increase A␤ deposition and tau phosphorylation or are killed/incapacitated by A␤, an antimicrobial peptide that is part of the innate immune defense system. Representatives of these pathogens target multiple AD GWAS genes, and their interactomes are enriched in genes related to the AD hippocampal tran.....
    Document: Multiple and diverse pathogens (bacteria, viruses, fungi, and spirochetes) have been detected in the AD brain and many cause neurodegeneration, increase A␤ deposition and tau phosphorylation or are killed/incapacitated by A␤, an antimicrobial peptide that is part of the innate immune defense system. Representatives of these pathogens target multiple AD GWAS genes, and their interactomes are enriched in genes related to the AD hippocampal transcriptome and to the proteins found in AD plaques and tangles. The upregulated genes of the AD hippocampal transcriptome also correspond to those upregulated by multiple species of viral, bacterial, fungal, and protozoan pathogens or by interferon gamma and TLR ligands.

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