Selected article for: "ad disease and ad potential"
Author: Carter, Chris J.
Title: Genetic, Transcriptome, Proteomic, and Epidemiological Evidence for Blood-Brain Barrier Disruption and Polymicrobial Brain Invasion as Determinant Factors in Alzheimer’s Disease
  • Document date: 2017_9_28
    • ID: tmpidjrp_87
    Snippet: Amelioration of BBB disruption has already been proposed as a potential therapy in AD, and several drugs including angiotensin receptor blockers, etodolac (NSAID), granisetron (5HT3 serotonin receptor antagonist), or beclomethasone (corticosteroid) [249, 250] as well as other NSAIDS, statins, Table 1 The effects of Alzheimer's disease (AD) environmental risk factors and beneficial agents on blood-brain barrier (BBB) function AD risk factor Effect.....
    Document: Amelioration of BBB disruption has already been proposed as a potential therapy in AD, and several drugs including angiotensin receptor blockers, etodolac (NSAID), granisetron (5HT3 serotonin receptor antagonist), or beclomethasone (corticosteroid) [249, 250] as well as other NSAIDS, statins, Table 1 The effects of Alzheimer's disease (AD) environmental risk factors and beneficial agents on blood-brain barrier (BBB) function AD risk factor Effects on BBB Aging Aging leads to barrier dysfunction and vascular hyperpermeability in peripheral and BBB [165] Air pollution Long-term air pollution disrupts the BBB in children and young adults and causes neuroinflammation, an altered brain innate immune response, and accumulation of A␤ and alpha-synuclein starting in childhood [ Mild traumatic brain injury produces early disruption of the BBB in animal models and in human [287, 288] . Cerebral hypoperfusion/ischemia (Caused by carotid/leptomeningeal/circle of Willis atherosclerosis or by hypotension)

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