Author: Jin, Xi; Lian, Jiang-Shan; Hu, Jian-Hua; Gao, Jianguo; Zheng, Lin; Zhang, Yi-Min; Hao, Shao-Rui; Jia, Hong-Yu; Cai, Huan; Zhang, Xiao-Li; Yu, Guo-Dong; Xu, Kai-Jin; Wang, Xiao-Yan; Gu, Jue-Qing; Zhang, Shan-Yan; Ye, Chan-Yuan; Jin, Ci-Liang; Lu, Ying-Feng; Yu, Xia; Yu, Xiao-Peng; Huang, Jian-Rong; Xu, Kang-Li; Ni, Qin; Yu, Cheng-Bo; Zhu, Biao; Li, Yong-Tao; Liu, Jun; Zhao, Hong; Zhang, Xuan; Yu, Liang; Guo, Yong-Zheng; Su, Jun-Wei; Tao, Jing-Jing; Lang, Guan-Jing; Wu, Xiao-Xin; Wu, Wen-Rui; Qv, Ting-Ting; Xiang, Dai-Rong; Yi, Ping; Shi, Ding; Chen, Yanfei; Ren, Yue; Qiu, Yun-Qing; Li, Lan-Juan; Sheng, Jifang; Yang, Yida
Title: Epidemiological, clinical and virological characteristics of 74 cases of coronavirus-infected disease 2019 (COVID-19) with gastrointestinal symptoms Document date: 2020_3_24
ID: zph6r4il_36
Snippet: A large reservoir of SARS-like bat coronavirus has the capacity to efficiently use the human ACE2 receptor for docking, replication and entry. 27 ACE2 is predominantly expressed in human alveolar cells and intestinal epithelial cells. The binding force change is caused by the sequence mutation of SARS-CoV-2, which merits further investigation. We found that the electrostatic changes between ZJ01 and Wuhan-Hu-1 were highly concentrated in the muta.....
Document: A large reservoir of SARS-like bat coronavirus has the capacity to efficiently use the human ACE2 receptor for docking, replication and entry. 27 ACE2 is predominantly expressed in human alveolar cells and intestinal epithelial cells. The binding force change is caused by the sequence mutation of SARS-CoV-2, which merits further investigation. We found that the electrostatic changes between ZJ01 and Wuhan-Hu-1 were highly concentrated in the mutation zone of S2 (the portion of S protein which promotes the fusion of the virus into host cells). Therefore, further studies exploring the underlining mechanisms for these conformations and binding force changes are urgently needed. These may help explain the increased GI symptoms in the later phase of this virus outbreak and their novel epidemiological/clinical features.
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