Author: Im, Kyungtaek; Kim, Jisu; Min, Hyeyoung
Title: Ginseng, the natural effectual antiviral: Protective effects of Korean Red Ginseng against viral infection Document date: 2015_9_16
ID: u800148j_8
Snippet: In addition, RGE protected human epithelial cells from RSVinduced cell death and viral replication and inhibited the production of proinflammatory cytokines in vitro upon RSV infection [20, 21] . Moreover, RGE treatment improved clinical outcomes by preventing weight loss and increasing viral clearance and IFN-g production in bronchoalveolar lavage cells in mice [20, 21] . RGE also increased the numbers of CD11cþ dendritic cells, IFN-g-secreting.....
Document: In addition, RGE protected human epithelial cells from RSVinduced cell death and viral replication and inhibited the production of proinflammatory cytokines in vitro upon RSV infection [20, 21] . Moreover, RGE treatment improved clinical outcomes by preventing weight loss and increasing viral clearance and IFN-g production in bronchoalveolar lavage cells in mice [20, 21] . RGE also increased the numbers of CD11cþ dendritic cells, IFN-g-secreting CD8þ T cells, and CD4þ T cells in bronchoalveolar lavage fluids [20, 21] . Taken together, these studies demonstrate that ginseng has immunomodulatory and antiviral effects against RSV infection through multiple mechanisms, and further studies are required to elucidate the underlying immunoregulatory and antiviral mechanisms at the molecular level.
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