Clinical Decision Support Tool and Rapid Point-of-Care Platform for Determining Disease Severity in Patients with COVID-19

Michael P McRae; Glennon W Simmons; Nicolaos J Christodoulides; Zhibing Lu; Stella K Kang; David Fenyo; Timothy Alcorn; Isaac P Dapkins; Iman Sharif; Deniz Vurmaz; Sayli S Modak; Kritika Srinivasan; Shruti Warhadpande; Ravi Shrivastav; John T McDevitt

Having identified a method to measure strategic biomarkers in a multiplexed panel, this next step involves the translation of these test values alongside key clinical metrics into information relevant to COVID-19 disease severity. A COVID-19 Disease Severity model was developed based on data from 160 hospitalized patients from Wuhan, China. 14 Here, 160 patients with hypertension were admitted to the hospital for COVID-19 in which 117 were eventually discharged and 43 died. Table 3 summarizes the patient characteristics and lab values for both patient groups. Interestingly, males accounted for 70% of the deaths vs. 44% of the discharged patients. This study finds significantly higher levels of biomarkers (cTnI, CK-MB, MYO, CRP, and PCT) in patients that died vs. those that were discharged. Likewise, age was a statistically significant factor with mean (SD) of 63 (13) and 73 (8) in the "discharged" and "died" groups, respectively.