Author: Liu, Chunxi; Liu, Tingxian; Yu, Xiaoyue; Gu, Yizhu
Title: A preliminary study on the interaction between Asn-Gly-Arg (NGR)-modified multifunctional nanoparticles and vascular epithelial cells Document date: 2017_4_1
ID: xio0g203_59
Snippet: Subsequently, TPIC was demonstrated to co-localize with CAV1 and enter into HUVEC together with CAV1 (Fig. 5B) . However, compared with their interaction with CD13, TPIC did not cause CAV1 clustering, suggesting that the co-localization of TPIC and CAV1 did not result from the receptor-ligand interaction of CD13 and NGR. Moreover, some TPIC were internalized independent of CAV1 (red dots), suggesting that there might be other mechanisms independe.....
Document: Subsequently, TPIC was demonstrated to co-localize with CAV1 and enter into HUVEC together with CAV1 (Fig. 5B) . However, compared with their interaction with CD13, TPIC did not cause CAV1 clustering, suggesting that the co-localization of TPIC and CAV1 did not result from the receptor-ligand interaction of CD13 and NGR. Moreover, some TPIC were internalized independent of CAV1 (red dots), suggesting that there might be other mechanisms independent of CAV1, such as CME. We then verified that CME was indeed involved by the following endocytosis inhibitor experiments, which revealed results consistent with our hypothesis from previous studies 34 .
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