Author: Carter, Chris J.
Title: Genetic, Transcriptome, Proteomic, and Epidemiological Evidence for Blood-Brain Barrier Disruption and Polymicrobial Brain Invasion as Determinant Factors in Alzheimer’s Disease Document date: 2017_9_28
ID: tmpidjrp_12
Snippet: Many AD gene variants from genome-wide association studies (GWAS) also converge towards the common effect of increasing A⤠production [78, 79] . In the circulation, amyloid-⤠protein precursor (Aâ¤PP) and â¥-secretase are highly expressed in the dendritic cells that scout for invading pathogens [80] . In this context, enhanced A⤠production can also be considered as evolutionarily advantageous [81] . This theme is carried through in postm.....
Document: Many AD gene variants from genome-wide association studies (GWAS) also converge towards the common effect of increasing A⤠production [78, 79] . In the circulation, amyloid-⤠protein precursor (Aâ¤PP) and â¥-secretase are highly expressed in the dendritic cells that scout for invading pathogens [80] . In this context, enhanced A⤠production can also be considered as evolutionarily advantageous [81] . This theme is carried through in postmortem studies showing that neuroinflammatory changes are prevalent in vulnerable regions of the AD brain [82, 83] . The proteins found in plaques and tangles also contain many related to the immune system, inflammation and autophagy, all of which play a general role in pathogen defense [84] [85] [86] as does Aâ¤.
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