Author: Carter, Chris J.
Title: Genetic, Transcriptome, Proteomic, and Epidemiological Evidence for Blood-Brain Barrier Disruption and Polymicrobial Brain Invasion as Determinant Factors in Alzheimer’s Disease Document date: 2017_9_28
ID: tmpidjrp_18
Snippet: Different types of pathogens are detected by a large family of pattern recognition receptors, for example toll-like receptors (TLRs) or nucleotide binding oligomerization domain (NOD)-like receptors, c-type lectin receptors, RIG-I-like receptors, and intra-cytosolic DNA or RNA sensors, inter alia. Each relatively selectively reacts to bacterial or fungal components or to viral or other pathogens' DNA or RNA [98] . The pathogens addressed in this .....
Document: Different types of pathogens are detected by a large family of pattern recognition receptors, for example toll-like receptors (TLRs) or nucleotide binding oligomerization domain (NOD)-like receptors, c-type lectin receptors, RIG-I-like receptors, and intra-cytosolic DNA or RNA sensors, inter alia. Each relatively selectively reacts to bacterial or fungal components or to viral or other pathogens' DNA or RNA [98] . The pathogens addressed in this study each interact with subsets of these and other processes, for example antimicrobial peptides and antiviral genes, specifically related to infection. These pathogen-specific aspects were addressed by a survey of expression changes in the AD blood, CSF or brain, which were matched to the known effects of bacterial, viral and fungal representatives.
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