Genetic, Transcriptome, Proteomic, and Epidemiological Evidence for Blood-Brain Barrier Disruption and Polymicrobial Brain Invasion as Determinant Factors in Alzheimer’s Disease

Carter, Chris J.

Host/pathogen interactomes are enriched in AD genes ( Fig. 2) All host/pathogen interactomes, except those of the Borna virus, Ebola virus, and the HERV-W retrovirus were significantly enriched in AD genes (FDR p < 0.05). Pathogen burden (cytomegalovirus, Fig. 2 . The number of AD genes (of 78) overlapping with diverse host/pathogen interactomes, or with those implicated in pathogen, protozoan, or viral diversity or with the immune response to parasitic worms (Helminth). The identities on the X-axis (e.g., C. albicans (1471|5.2) are appended with the total number of genes in each interactome (1471 in this case) or genetics dataset followed by the enrichment ratio (5.2 fold). The FDR-corrected p value for enrichment is shown on the right hand axis which is set to a maximum of 0.05. Invisible points are above this value. The Bonferroni cut-off level (p = 0.05/78) is also shown. The Burden data (lighter shaded bar) correspond to the combined interactomes of the human cytomegalovirus, HSV-1, B. burgdorferi, C. pneumoniae, and H. pylori.