Author: Carter, Chris J.
Title: Genetic, Transcriptome, Proteomic, and Epidemiological Evidence for Blood-Brain Barrier Disruption and Polymicrobial Brain Invasion as Determinant Factors in Alzheimer’s Disease Document date: 2017_9_28
ID: tmpidjrp_51
Snippet: Host/pathogen interactome enrichment in misregulated genes of the AD hippocampal transcriptome (Fig. 4) All pathogen interactomes, most notably relating to influenza, C. neoformans, and Hepatitis C were highly enriched in genes relating to this microarray dataset (combined up and downregulated hippocampal genes in AD). The significance level of the interactome enrichment for most pathogens was several orders of magnitude below the Bonferroni cut .....
Document: Host/pathogen interactome enrichment in misregulated genes of the AD hippocampal transcriptome (Fig. 4) All pathogen interactomes, most notably relating to influenza, C. neoformans, and Hepatitis C were highly enriched in genes relating to this microarray dataset (combined up and downregulated hippocampal genes in AD). The significance level of the interactome enrichment for most pathogens was several orders of magnitude below the Bonferroni cut off (p = 1.74E-05) (Fig. 4) . Regarding the influenza data, bronchopneumonia, often caused by influenza, is a common final cause of death in dementia patients [147] and such recent infections close to death may well influence the data.
Search related documents:
Co phrase search for related documents- AD hippocampal transcriptome and Host pathogen: 1, 2
- common death final cause and death final cause: 1
- common death final cause and final cause: 1
- death final cause and final cause: 1, 2
Co phrase search for related documents, hyperlinks ordered by date