Author: Carter, Chris J.
Title: Genetic, Transcriptome, Proteomic, and Epidemiological Evidence for Blood-Brain Barrier Disruption and Polymicrobial Brain Invasion as Determinant Factors in Alzheimer’s Disease Document date: 2017_9_28
ID: tmpidjrp_10
Snippet: Many AD genes encode proteins that physically interact within a defined protein/protein interaction network, and this network has been subject to positive selection pressure. Selection for pathogen resistance was proposed as one possible explanation [65] . Pathogens have shaped human evolution and the development of the immune and pathogen defense mechanisms, endowing descendants of the survivors of dangerous infections with resistance genes [66].....
Document: Many AD genes encode proteins that physically interact within a defined protein/protein interaction network, and this network has been subject to positive selection pressure. Selection for pathogen resistance was proposed as one possible explanation [65] . Pathogens have shaped human evolution and the development of the immune and pathogen defense mechanisms, endowing descendants of the survivors of dangerous infections with resistance genes [66] [67] [68] .
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