Author: Carter, Chris J.
Title: Genetic, Transcriptome, Proteomic, and Epidemiological Evidence for Blood-Brain Barrier Disruption and Polymicrobial Brain Invasion as Determinant Factors in Alzheimer’s Disease Document date: 2017_9_28
ID: tmpidjrp_32
Snippet: AD GWAS genes are enriched in immune locations ( Fig. 1) The AD genes are most significantly enriched in the exosome and bone marrow datasets. As noted above, exosomes are hijacked by many viruses for intercellular spread. Exosomes are prevalent in plasma [111] (also enriched in AD genes) and are also the means by which intracellularly generated The bars indicate the number of genes (from 78) in each tissue (Y1 axis) and the dotted line the FDR c.....
Document: AD GWAS genes are enriched in immune locations ( Fig. 1) The AD genes are most significantly enriched in the exosome and bone marrow datasets. As noted above, exosomes are hijacked by many viruses for intercellular spread. Exosomes are prevalent in plasma [111] (also enriched in AD genes) and are also the means by which intracellularly generated The bars indicate the number of genes (from 78) in each tissue (Y1 axis) and the dotted line the FDR corrected p value (q value). The maximum on the Y2 axis is set to q = 0.05. Observed/expected values, followed by the total number of genes expressed per tissue, are appended after the identities of each sample on the X axis. BBB refers to a separate blood-brain barrier proteomics dataset.
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