Selected article for: "antibody response and humoral response"
Author: Michael P McRae; Glennon W Simmons; Nicolaos J Christodoulides; Zhibing Lu; Stella K Kang; David Fenyo; Timothy Alcorn; Isaac P Dapkins; Iman Sharif; Deniz Vurmaz; Sayli S Modak; Kritika Srinivasan; Shruti Warhadpande; Ravi Shrivastav; John T McDevitt
Title: Clinical Decision Support Tool and Rapid Point-of-Care Platform for Determining Disease Severity in Patients with COVID-19
  • Document date: 2020_4_22
    • ID: h4lsvgxo_32
    Snippet: The second relevant diagnostic test involves detecting this antibody response as an indicator of exposure and subsequent immune response to the virus. The humoral immune response usually begins with the production of IgM antibodies. IgM antibodies tend to have low affinity since they are produced before B cells undergo somatic hypermutation; however, IgM is pentameric in structure, making it an effective activator of the complement system which i.....
    Document: The second relevant diagnostic test involves detecting this antibody response as an indicator of exposure and subsequent immune response to the virus. The humoral immune response usually begins with the production of IgM antibodies. IgM antibodies tend to have low affinity since they are produced before B cells undergo somatic hypermutation; however, IgM is pentameric in structure, making it an effective activator of the complement system which is important in controlling infections of the bloodstream. The monomeric IgG dominates the later phases of the antibody response. 30 A test for coronavirus exposure and immune response uses viral antigen to detect these antibodies in the bloodstream.

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