Author: Maddamsetti, Rohan; Johnson, Daniel T.; Spielman, Stephanie J.; Petrie, Katherine L.; Marks, Debora S.; Meyer, Justin R.
Title: Gain-of-function experiments with bacteriophage lambda uncover residues under diversifying selection in nature Document date: 2018_9_11
ID: z7alrc7s_26
Snippet: To study J evolution, we constructed two separate phylogenies, one for the entire J protein (Fig. 3A) and one for the specificity region (Fig. 3B ). In line with the SBP recombination breakpoint analysis previously discussed (Methods), these analyses lead to vastly different phylogenies (normalized Robinson-Foulds distance = 0.93 out of 1.00, normalized geodesic distance = 0.73 out of 1.00). This result suggests that there is frequent recombinati.....
Document: To study J evolution, we constructed two separate phylogenies, one for the entire J protein (Fig. 3A) and one for the specificity region (Fig. 3B ). In line with the SBP recombination breakpoint analysis previously discussed (Methods), these analyses lead to vastly different phylogenies (normalized Robinson-Foulds distance = 0.93 out of 1.00, normalized geodesic distance = 0.73 out of 1.00). This result suggests that there is frequent recombination and gene transfer between these two gene regions, causing each to inherit different evolutionary histories.
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