Gene Expression Profile during Chondrogenesis in Human Bone Marrow derived Mesenchymal Stem Cells using a cDNA Microarray

Yoo, Hyun Jung; Yoon, Sung Soo; Park, Seon Yang; Lee, Eun Young; Lee, Eun Bong; Kim, Ju Han; Song, Yeong Wook

Axl is overexpressed in a number of tumors (10) , and IL-15 is known to mediate the transactivation and upregulation of Axl with subsequent activation of PI3K/Akt and upregulations of Bcl-2 and Bcl-XL (11) . On the other hand, synaptotagmin IV is required for the maturation of secretory granules in PC12 cells (12) . Human homologues of yeast Rad 6 (Hrad6B) encode ubiq-uitin-conjugating enzymes, and is highly expressed in lung cancer cell. It has been reported that DNA repair and UV mutagenesis are defective in Saccharomyces cerevisiae rad6 mutant (13) . Peroxiredoxin-1 is the most ubiquitously expressed member of the peroxiredoxin family, and is found in the cytoplasm, nucleus, mitochondria, and peroxisomes of many cell types (14) . Furthermore, recent studies have reported high levels of peroxiredoxin-1 expression in the bovine bladder, seminal vesicles, testes, adrenal gland (15) , and in the rat liver, skin, lungs and nervous system (14) . The role of peroxiredoxin-1 in cell differentiation and proliferation suggests that it has a possible role in growth and development.