Selected article for: "influenza vaccine and vaccine development"
Author: Karch, Christopher P; Matyas, Gary R; Burkhard, Peter; Beck, Zoltan
Title: Glycosylation of the HIV-1 Env V1V2 loop to form a native-like structure may not be essential with a nanoparticle vaccine
  • Document date: 2019_1_10
    • ID: yhh3ydok_5
    Snippet: The use of a carrier may be essential to the development of a successful V1V2 vaccine candidate. One such technology is the self-assembling protein nanoparticle (SAPNs). SAPNs are built on coiled-coil protein folding domains, which are composed of two or more α-helices. Glycosylation of the HIV-1 Env V1V2 loop to form a native-like structure may not be essential with a nanoparticle vaccine [32] . By choosing the correct combination of coiled-coi.....
    Document: The use of a carrier may be essential to the development of a successful V1V2 vaccine candidate. One such technology is the self-assembling protein nanoparticle (SAPNs). SAPNs are built on coiled-coil protein folding domains, which are composed of two or more α-helices. Glycosylation of the HIV-1 Env V1V2 loop to form a native-like structure may not be essential with a nanoparticle vaccine [32] . By choosing the correct combination of coiled-coil domains, protein folding can be optimized and the antigen of interest can be folded into a native-like conformation. This technology has been successfully applied in the development of influenza, SARS, toxoplasma and malaria vaccine candidates, in all of which the immunogens were unglycosylated [9, [33] [34] [35] [36] .

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