Author: Narrandes, Shavira; Xu, Wayne
Title: Gene Expression Detection Assay for Cancer Clinical Use Document date: 2018_6_5
ID: wheblwm3_2
Snippet: However, numerous challenges involved with tumor sample collection, experimental design and determining the proper assay to use, analytical and diagnostic factors (such as the interpretation of samples and biomarker performance analysis), assay detection limits and specificity, drug development for rare cancers, and clinical distribution of a significant biomarker must be overcome to develop a novel clinical assay for cancer patients. Biomarker d.....
Document: However, numerous challenges involved with tumor sample collection, experimental design and determining the proper assay to use, analytical and diagnostic factors (such as the interpretation of samples and biomarker performance analysis), assay detection limits and specificity, drug development for rare cancers, and clinical distribution of a significant biomarker must be overcome to develop a novel clinical assay for cancer patients. Biomarker development is also naturally affected by a patient's natural biology and history, intratumor heterogeneity, cancer progression, and germ-line mutations. This results in a prolonged period from the biomarker discovery to patenting and clinical translation stages. 4, 5 , 6 , 7 Therefore, we intend to provide a guideline for choosing an assay method with respect to its oncological applications in a clinical setting.
Search related documents:
Co phrase search for related documents- assay method and clinical assay: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- assay method and clinical setting: 1, 2
- assay method and clinical translation: 1
- assay method and detection limit: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- assay method and drug development: 1
- biomarker development and cancer progression: 1
- biomarker development and clinical assay: 1
- biomarker development and clinical setting: 1, 2, 3
- biomarker development and clinical translation: 1, 2, 3
- biomarker development and drug development: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13
- biomarker development and experimental design: 1
- biomarker discovery and cancer progression: 1
- biomarker discovery and clinical assay: 1, 2, 3
- biomarker discovery and clinical setting: 1, 2, 3
- biomarker discovery and clinical translation: 1, 2
- biomarker discovery and drug development: 1, 2, 3, 4, 5, 6
- biomarker discovery and experimental design: 1, 2
- biomarker performance and clinical assay: 1
- biomarker performance and detection limit: 1, 2, 3
Co phrase search for related documents, hyperlinks ordered by date