Author: Maddamsetti, Rohan; Johnson, Daniel T.; Spielman, Stephanie J.; Petrie, Katherine L.; Marks, Debora S.; Meyer, Justin R.
Title: Gain-of-function experiments with bacteriophage lambda uncover residues under diversifying selection in nature Document date: 2018_9_11
ID: z7alrc7s_40
Snippet: Additional supporting information may be found online in the Supporting Information section at the end of the article. Table S1 . Oligonucleotides (oligos) used to edit λ genomes. Table S2 . MAGE experiment design for 19-mutation library. Figure S1 . Occurrence of engineered MAGE substitutions in 1207 natural J sequences. Figure S2 . Phylogeny and alignment for residues 960-1132 of J protein. Figure S3 . Evolutionary rates for sites in the speci.....
Document: Additional supporting information may be found online in the Supporting Information section at the end of the article. Table S1 . Oligonucleotides (oligos) used to edit λ genomes. Table S2 . MAGE experiment design for 19-mutation library. Figure S1 . Occurrence of engineered MAGE substitutions in 1207 natural J sequences. Figure S2 . Phylogeny and alignment for residues 960-1132 of J protein. Figure S3 . Evolutionary rates for sites in the specificity region, calculated using LEISR. Figure S4 . Distribution of log 10 non-zero branch lengths in the full phylogeny for residues 960-1132 including all 1,207 J homologs. Figure S5 . Visualization of geodesic distances between λ protein phylogenies by metric multidimensional scaling. Data S1. Alignment of 1207 full-length J homologs analyzed in this paper.
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