Author: Carter, Chris J.
Title: Genetic, Transcriptome, Proteomic, and Epidemiological Evidence for Blood-Brain Barrier Disruption and Polymicrobial Brain Invasion as Determinant Factors in Alzheimer’s Disease Document date: 2017_9_28
ID: tmpidjrp_2
Snippet: Pathogens that have been detected in the AD brain using DNA detection or immunocytochemistry include HSV-1, C. Pneumoniae, B. Burgdorferi, and many other spirochetes [33] [34] [35] , human herpes virus 6 (HHV-6) [36] , the Epstein-Barr virus (EBV) [37] , and Propionibacterium acnes [38] . Bacterial LPS, an immunogenic component of the outer coat of gram-negative bacteria, and E coli K99 (a filamentous fimbrial thread that attaches to other bacter.....
Document: Pathogens that have been detected in the AD brain using DNA detection or immunocytochemistry include HSV-1, C. Pneumoniae, B. Burgdorferi, and many other spirochetes [33] [34] [35] , human herpes virus 6 (HHV-6) [36] , the Epstein-Barr virus (EBV) [37] , and Propionibacterium acnes [38] . Bacterial LPS, an immunogenic component of the outer coat of gram-negative bacteria, and E coli K99 (a filamentous fimbrial thread that attaches to other bacteria or host cells) were detected immunocytochemically in brain parenchyma and vessels in all AD (24/24) and control brains (18/18) . K99 levels were greater in AD compared to control brains and K99 was localized to neuron-like cells in AD but not control brains. LPS levels were also greater in AD compared to control brain and LPS colocalized with A⤠in amyloid plaques and around vessels in AD brains [39] . P. gingivalis LPS has also been detected in AD brains postmortem [40] .
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