Selected article for: "BBB disruption and ischemic stroke"
Author: Carter, Chris J.
Title: Genetic, Transcriptome, Proteomic, and Epidemiological Evidence for Blood-Brain Barrier Disruption and Polymicrobial Brain Invasion as Determinant Factors in Alzheimer’s Disease
  • Document date: 2017_9_28
    • ID: tmpidjrp_92
    Snippet: Theobromine is a phosphodiesterase inhibitor and downregulates PDE4 in a glioma cell line [317] . PDE4 inhibition (rolipram) reduces BBB damage in ischemic stroke in mice [318] . Caffeine and theobromine are adenosine receptor antagonists [319] . Extracellular adenosine increases BBB permeability and adenosine receptor antagonism blocks the entry of inflammatory cells and soluble factors into the brain [320] Folic acid Vitamin B12-B6-folate treat.....
    Document: Theobromine is a phosphodiesterase inhibitor and downregulates PDE4 in a glioma cell line [317] . PDE4 inhibition (rolipram) reduces BBB damage in ischemic stroke in mice [318] . Caffeine and theobromine are adenosine receptor antagonists [319] . Extracellular adenosine increases BBB permeability and adenosine receptor antagonism blocks the entry of inflammatory cells and soluble factors into the brain [320] Folic acid Vitamin B12-B6-folate treatment improves BBB function in patients with hyperhomocysteinemia and mild cognitive impairment [321] . Folic acid decreases BBB leakage and reactive astrogliosis following seizures in pregnant and prepubertal rats [322] (Continued) Estrogen protects against BBB breakdown in animal models of stroke or following LPS challenge and maintains barrier integrity [324] [325] [326] [327] Components of the Mediterranean diet Omega-3 fatty acids reduce BBB disruption in hypoxic/ischemic brain injury [328] . Fish oil reduces BBB disruption in a rat model of juvenile traumatic brain injury [329] . Virgin olive oil reduces BBB permeability following middle cerebral artery occlusion in rats [330] . Aged garlic extract protects against BBB disruption caused by a high saturated fatty acid diet in mice [331] . Resveratrol, a component of grape and red fruit skins, and red wine [332] , maintains the integrity of the BBB after cerebral ischemia reperfusion in rats [333] Statins

    Search related documents:
    Co phrase search for related documents
    • adenosine receptor and brain injury: 1
    • adenosine receptor and cognitive impairment: 1
    • adenosine receptor and Extracellular adenosine: 1, 2, 3, 4, 5
    • adenosine receptor antagonist and Extracellular adenosine: 1, 2
    • animal model and artery occlusion: 1, 2, 3, 4, 5, 6, 7, 8, 9
    • animal model and BBB permeability: 1, 2
    • animal model and brain injury: 1, 2, 3, 4, 5, 6, 7, 8, 9
    • animal model and cell line: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15
    • animal model and cognitive impairment: 1, 2, 3
    • artery occlusion and barrier integrity: 1, 2, 3, 4, 5, 6
    • artery occlusion and BBB damage: 1, 2, 3
    • artery occlusion and BBB disruption: 1, 2, 3, 4, 5
    • artery occlusion and BBB integrity: 1, 2, 3, 4
    • artery occlusion and BBB leakage: 1, 2
    • artery occlusion and BBB permeability: 1, 2, 3, 4
    • artery occlusion and brain injury: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22
    • artery occlusion and cognitive impairment: 1, 2
    • barrier integrity and cell line: 1, 2, 3
    • barrier integrity and cognitive impairment: 1, 2