Author: Narrandes, Shavira; Xu, Wayne
Title: Gene Expression Detection Assay for Cancer Clinical Use Document date: 2018_6_5
ID: wheblwm3_57
Snippet: As discussed earlier, each of the five assays have been use in clinical-related studies to analyze the gene expression from cancer patient samples. The qRT-PCR, DNA microarray, and NanoString nCounter assays have commercialized products (Oncotype DX, MammaPrint, and PROSIGNA, respectively) for testing clinical samples. Illumina MiSeq does not have such an assay, yet one can send samples to an institute for processing. 116,117 Tissue microarrays a.....
Document: As discussed earlier, each of the five assays have been use in clinical-related studies to analyze the gene expression from cancer patient samples. The qRT-PCR, DNA microarray, and NanoString nCounter assays have commercialized products (Oncotype DX, MammaPrint, and PROSIGNA, respectively) for testing clinical samples. Illumina MiSeq does not have such an assay, yet one can send samples to an institute for processing. 116,117 Tissue microarrays also do not have a commercialized assay as they are used to detect up to a few genes in a maximum of 1000 samples, requiring a cohort of patient samples to be gathered to construct a TMA. They are therefore ideal for validating studies using qRT-PCR, DNA microarrays, et cetera, and not for the assessment of individual or a small number of samples.
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